Microwave Assisted Synthesis of Indolyl Chalcones

Author(s): Deekshaputra R. Birhade

Abstract:

Chalcones exhibit diverse pharmacological activities such as antimalarial, anti-inflammatory, antitubercular, antioxidant, anti-AIDS, antibacterial, antileishmanial, anticancer, antipyretic and analgesic. Some chalcones possess bactericidal, antifungal and insecticidal activity and some of their derivatives are reported to be chemo preventive activity, antimutagenic, cardiovascular disease, cytotoxic activity, antiprolifirative activity and antiviral activity and have been used as intermediate for the preparations of compounds having therapeutic value. Indole heterocycles are also an important bioactive compounds and it serves as a fundamental skeleton in naturally occurring alkaloids. Indole derivatives are known for their role as insecticidal, antimicrobial, painkillers, antiviral, antiinflammatory, anti-tubercular, depression medications, antineoplastic, antioxidants, antihypertensives, and anti-diabetic agents. In this work, we in search of new bioactive compounds Indole and different ketones are used to prepare a series of Indolyl-chalcones (3a-g) by microwave irradiation method and characterized by different spectroscopic techniques.

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