Biomedical Applications of Nano-Metal-Organic Frameworks

Author(s): Krishna Ghosh, Touhida Parveen and Tanmay Chattopadhyay

Abstract:

Nanomaterials (NMs) possess extremely small dimensions, which significantly enhance their surface modification capabilities, surface-to-volume ratio, and a range of other unique physicochemical properties. Due to these characteristics, NMs are widely utilized across various research fields. In recent years, the biomedical applications of metal–organic frameworks (MOFs) have attracted considerable attention. MOFs are a class of porous materials composed of metal ions or clusters coordinated to organic ligands, forming hybrid crystalline structures. These materials offer tunable pore sizes, defined active sites, high surface area, and structural versatility, making them particularly suitable for biomedical applications. Based on pore size, MOFs can be categorized into microporous, mesoporous, and nanoporous types. Among their biomedical applications, MOFs are being extensively investigated for drug delivery, cancer treatment, tumor therapy, antiviral therapy, and bioimaging. This review provides an overview of the various types of MOFs employed in biomedical contexts, with a particular focus on their synergistic therapeutic strategies and corresponding efficacy. Finally, we address the current challenges and future prospects in advancing MOF-based systems for drug delivery and cancer therapy.

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Pages: 110-115     |    3 View     |    0 Download